Redesigning Life: How Genome Editing Will Transform the World by
Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximize agricultural production and cater to our tastes in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin's theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering.In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. "Mutation chain reaction" can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch.These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring - and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.
Eugenics: a Very Short Introduction by
In 1883, Francis Galton, a cousin of Charles Darwin, coined the word "eugenics" to express his dream of perfecting the human race by applying the laws of genetic heredity. Adapting Darwin's theory of evolution to human society, eugenics soon became a powerful, international movement, committed to using the principles of heredity and statistics to encourage healthy and discourage unhealthy reproduction. Early in the twentieth century and across the world, doctors, social reformers, and politicians turned to the new science of eugenics as a means to improve and strengthen their populations. Eugenics advocates claimed their methods would result in healthier, fitter babies and would dramatically limit human suffering. The reality was a different story. In the name of scientific progress and of human improvement, eugenicists targeted the weak and the sick, triggering coercive legislation on issues as disparate as race, gender, immigration, euthanasia, abortion, sterilization, intelligence, mental illness, and disease control. Nationalists eagerly embraced eugenics as a means to legitimize their countries' superiority and racialized assumptions, and the Nazis notoriously used eugenics to shape their "final solution." In this lucid volume, Philippa Levine tackles the intricate and controversial history of eugenics, masterfully synthesizing the enormous range of policies and experiments carried out in the name of eugenics around the world throughout the twentieth century. She questions the widespread belief that eugenics disappeared after World War II and evaluates the impact of eugenics on current reproductive and genetic sciences. Charting the development of such controversial practices as artificial insemination, sperm donation, and population control, this book offers a powerful, extraordinarily timely reflection on the frequent interplay between genetics and ethics. Eugenics may no longer be a household word, but we feel its effects even today.